InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il1rl1

Summary

InnateDB Protein

IDBP-148427.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il1rl1

Protein Name

interleukin 1 receptor-like 1

Synonyms

DER4; Fit-1; Ly84; St2; St2-rs1; ST2L; T1; T1/ST2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054914

InnateDB Gene

IDBG-148423 (Il1rl1)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 (By similarity). Possibly involved in helper T-cell function. {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.Isoform B: Secreted.

Disease Associations

Tissue Specificity

Predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines. {ECO:0000269PubMed:8131748}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002113	interleukin-33 binding
GO:0002114	interleukin-33 receptor activity
GO:0004908	interleukin-1 receptor activity
GO:0005515	protein binding

Biological Process

GO:0002826	negative regulation of T-helper 1 type immune response
GO:0007165	signal transduction
GO:0032689	negative regulation of interferon-gamma production
GO:0032754	positive regulation of interleukin-5 production
GO:0038172	interleukin-33-mediated signaling pathway
GO:0043032	positive regulation of macrophage activation
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0050729	positive regulation of inflammatory response
GO:0090197	positive regulation of chemokine secretion

Cellular Component

GO:0005576	extracellular region
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:98427

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR004074 Interleukin-1 receptor type I/II
IPR007110 Immunoglobulin-like domain
IPR013151 Immunoglobulin

PFAM

PF01582
PF13676
PF00047

PRINTS

PR01536

PIRSF

SMART

SM00255
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt