Version 5.4
Homo sapiens Protein: PNOC
Summary
InnateDB Protein IDBP-14859.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PNOC
Protein Name prepronociceptin
Synonyms PPNOC;
Species Homo sapiens
Ensembl Protein ENSP00000301908
InnateDB Gene IDBG-14857 (PNOC)
Protein Structure
UniProt Annotation
Function Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation. {ECO:0000269PubMed:12950177}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001515 opioid peptide activity
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007218 neuropeptide signaling pathway
GO:0007268 synaptic transmission
GO:0007600 sensory perception
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR002367 Nociceptin
IPR006024 Opioid neuropeptide precursor
PFAM PF01160
PRINTS PR01031
PR01028
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13519
PhosphoSite PhosphoSite-Q13519
TrEMBL Q9BYY3
UniProt Splice Variant
Entrez Gene 5368
UniGene Hs.88218
RefSeq NP_006219
HUGO HGNC:9163
OMIM 601459
CCDS CCDS6066
HPRD 03268
IMGT
EMBL AC021678 AK301456 AY011845 AY335948 BC034758 BT019334 CH471080 CR541940 CR541965 U48263 X97367 X97368 X97370
GenPept AAC50651 AAG38294 AAH34758 AAP94601 AAV38141 BAH13485 CAA66039 CAA66040 CAG46738 CAG46763 EAW63526 EAW63527

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca