InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SGCG

Summary

InnateDB Protein

IDBP-14869.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SGCG

Protein Name

sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)

Synonyms

A4; DAGA4; DMDA; DMDA1; LGMD2C; MAM; SCARMD2; SCG3; TYPE;

Species

Homo sapiens

Ensembl Protein

ENSP00000218867

InnateDB Gene

IDBG-14867 (SGCG)

Protein Structure

UniProt Annotation

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Subcellular Localization

Cell membrane, sarcolemma {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Limb-girdle muscular dystrophy 2C (LGMD2C) [MIM:253700]: An autosomal recessive degenerative myopathy characterized by rapidly progressive muscle wasting from early childhood with loss of independent ambulation around age 12 years, dystrophic pattern on muscle biopsy, absence of gamma-sarcoglycan and normal dystrophin immunostaining. {ECO:0000269PubMed:10714584, ECO:0000269PubMed:8968757}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in skeletal and heart muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007517

muscle organ development

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016011	dystroglycan complex
GO:0016012	sarcoglycan complex
GO:0016021	integral component of membrane
GO:0042383	sarcolemma