Version 5.4
Homo sapiens Gene: SGCG
Summary
InnateDB Gene IDBG-14867.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SGCG
Gene Name sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
Synonyms A4; DAGA4; DMDA; DMDA1; LGMD2C; MAM; SCARMD2; SCG3; TYPE
Species Homo sapiens
Ensembl Gene ENSG00000102683
Encoded Proteins
IDBP-14869
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:23180952-23325165
Strand Forward strand
Band q12.12
Transcripts
ENST00000218867 ENSP00000218867
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007517 muscle organ development
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016011 dystroglycan complex
GO:0016012 sarcoglycan complex
GO:0016021 integral component of membrane
GO:0042383 sarcolemma
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035296
View Gene Order
ENSBTAG00000001865
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
hsa05416
Viral myocarditis pathway
INOH
PID NCI
Cross-References
SwissProt Q13326
TrEMBL
UniProt Splice Variant
Entrez Gene 6445
UniGene Hs.37167
RefSeq NM_000231 XM_005266505 XM_006719861
HUGO HGNC:10809
OMIM 608896
CCDS CCDS9299
HPRD
IMGT
EMBL AL157766 AL160256 AL356287 BC074777 BC074778 BC109321 U34976 U63389 U63390 U63391 U63392 U63393 U63394 U63395
GenPept AAC50269 AAD13475 AAH74777 AAH74778 AAI09322 CAI13924 CAI16053 CAI16544
RNA Seq Atlas 6445

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca