InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RXFP3

Summary

InnateDB Protein

IDBP-14872.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RXFP3

Protein Name

relaxin/insulin-like family peptide receptor 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000328708

InnateDB Gene

IDBG-14870 (RXFP3)

Protein Structure

UniProt Annotation

Function

Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation. {ECO:0000269PubMed:14522968}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008528	G-protein coupled peptide receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0032467	positive regulation of cytokinesis
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway