InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxa3

Summary

InnateDB Protein

IDBP-149070.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxa3

Protein Name

forkhead box A3

Synonyms

Hnf-3g; Hnf3g; Tcf-3g; Tcf3g;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043173

InnateDB Gene

IDBG-149068 (Foxa3)

Protein Structure

UniProt Annotation

Function

Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates GLUT2 transcription. Involved in regulation of neuronal-specific transcription. Involved in regulation of spermatogenesis; required for the maintenance of the testicular germ cell population and male fertility. {ECO:0000250, ECO:0000269PubMed:11546810, ECO:0000269PubMed:17488644, ECO:0000269PubMed:9632808}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Restricted mainly to endoderm-derived tissues (lung, liver, stomach, and small intestine), also present additionally in ovary, testis, heart, and adipose tissue, but missing from lung. {ECO:0000269PubMed:17488644}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001678	cellular glucose homeostasis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007283	spermatogenesis
GO:0007389	pattern specification process
GO:0009267	cellular response to starvation
GO:0009888	tissue development
GO:0010817	regulation of hormone levels
GO:0016568	chromatin modification
GO:0031018	endocrine pancreas development
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048665	neuron fate specification
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity