Version 5.4
Mus musculus Protein: Sympk
Summary
InnateDB Protein IDBP-149107.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sympk
Protein Name symplekin
Synonyms 1500016F02Rik; 4632415H16Rik; AA125406; AI449890; SPK; SYM;
Species Mus musculus
Ensembl Protein ENSMUSP00000023882
InnateDB Gene IDBG-149105 (Sympk)
Protein Structure
UniProt Annotation
Function Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house- keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, tight junction. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Cytoplasmic face of adhesion plaques (major) and nucleoplasm (minor) (in cells with TJ). Nucleoplasm (in cells without TJ). Nuclear bodies of heat-stressed cells (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006378 mRNA polyadenylation
GO:0007155 cell adhesion
GO:0035307 positive regulation of protein dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005923 tight junction
Protein Structure and Domains
PDB ID MGI:1915438
InterPro IPR016024 Armadillo-type fold
IPR022075 Symplekin C-terminal
PFAM PF12295
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80X82
PhosphoSite PhosphoSite-Q80X82
TrEMBL F8WJD4
UniProt Splice Variant
Entrez Gene 68188
UniGene Mm.130902
RefSeq NP_080881
MGI ID
MGI Symbol Sympk
OMIM
CCDS CCDS52051
HPRD
IMGT
EMBL AC170864 BC049852
GenPept AAH49852

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca