InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dlc1

Summary

InnateDB Protein

IDBP-149175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dlc1

Protein Name

deleted in liver cancer 1

Synonyms

A730069N07Rik; Arhgap7; dlc-1; HP; STARD12;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096425

InnateDB Gene

IDBG-149173 (Dlc1)

Protein Structure

UniProt Annotation

Function

Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with the highest levels in heart, liver and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0008289	lipid binding

Biological Process

GO:0001843	neural tube closure
GO:0003007	heart morphogenesis
GO:0007165	signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0021575	hindbrain morphogenesis
GO:0030036	actin cytoskeleton organization
GO:0030900	forebrain development
GO:0035023	regulation of Rho protein signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0048041	focal adhesion assembly