Version 5.4
Mus musculus Gene: Dlc1
Summary
InnateDB Gene IDBG-149173.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dlc1
Gene Name deleted in liver cancer 1
Synonyms A730069N07Rik; Arhgap7; dlc-1; HP; STARD12
Species Mus musculus
Ensembl Gene ENSMUSG00000031523
Encoded Proteins
IDBP-149175
deleted in liver cancer 1
IDBP-149177
deleted in liver cancer 1
IDBP-627541
deleted in liver cancer 1
IDBP-717987
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164741:
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:36567751-36953143
Strand Reverse strand
Band A4
Transcripts
ENSMUST00000098826 ENSMUSP00000096425
ENSMUST00000033923 ENSMUSP00000033923
ENSMUST00000036104
ENSMUST00000156312
ENSMUST00000145245
ENSMUST00000163663 ENSMUSP00000132812
ENSMUST00000179652
ENSMUST00000179501 ENSMUSP00000137498
ENSMUST00000178717
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0042169 SH2 domain binding
Biological Process
GO:0001843 neural tube closure
GO:0003007 heart morphogenesis
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0021575 hindbrain morphogenesis
GO:0030036 actin cytoskeleton organization
GO:0030336 negative regulation of cell migration
GO:0030900 forebrain development
GO:0032321 positive regulation of Rho GTPase activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0035023 regulation of Rho protein signal transduction
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035307 positive regulation of protein dephosphorylation
GO:0043547 positive regulation of GTPase activity
GO:0048041 focal adhesion assembly
GO:0051497 negative regulation of stress fiber assembly
GO:1900119 positive regulation of execution phase of apoptosis
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164741
View Gene Order
ENSBTAG00000015541
Not yet available
Pathways
NETPATH
REACTOME
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.125155 Mm.210875 Mm.407976 Mm.427616
RefSeq NM_001194940 NM_001194941 NM_015802 XM_006509166
OMIM
CCDS CCDS40322 CCDS57616 CCDS57617
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca