InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tiparp

Summary

InnateDB Protein

IDBP-149383.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tiparp

Protein Name

TCDD-inducible poly(ADP-ribose) polymerase

Synonyms

ARTD14; AW558171; PARP7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048051

InnateDB Gene

IDBG-149381 (Tiparp)

Protein Structure

UniProt Annotation

Function

Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals. {ECO:0000269PubMed:11716501}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:11716501}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0035326	enhancer binding
GO:0046872	metal ion binding

Biological Process

GO:0001570	vasculogenesis
GO:0001822	kidney development
GO:0006471	protein ADP-ribosylation
GO:0006807	nitrogen compound metabolic process
GO:0008209	androgen metabolic process
GO:0008210	estrogen metabolic process
GO:0008585	female gonad development
GO:0009791	post-embryonic development
GO:0010629	negative regulation of gene expression
GO:0030097	hemopoiesis
GO:0044236	multicellular organismal metabolic process
GO:0045732	positive regulation of protein catabolic process
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048705	skeletal system morphogenesis
GO:0048745	smooth muscle tissue development
GO:0060021	palate development
GO:0060325	face morphogenesis
GO:0071407	cellular response to organic cyclic compound