InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dmpk

Summary

InnateDB Protein

IDBP-149386.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dmpk

Protein Name

dystrophia myotonica-protein kinase

Synonyms

DM; Dm15; DMK; MDPK; MT-PK;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032568

InnateDB Gene

IDBG-149384 (Dmpk)

Protein Structure

UniProt Annotation

Function

Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. {ECO:0000269PubMed:12612014, ECO:0000269PubMed:15598648, ECO:0000269PubMed:18729234, ECO:0000269PubMed:21949239, ECO:0000269PubMed:9294109}.

Subcellular Localization

Sarcoplasmic reticulum membrane. Cell membrane. Note=Localizes to sarcoplasmic reticulum membranes of cardiomyocytes.Isoform 1: Endoplasmic reticulum membrane; Single-pass type IV membrane protein; Cytoplasmic side. Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.Isoform 8: Mitochondrion outer membrane; Single-pass type IV membrane protein.Isoform 5: Cytoplasm, cytosol.

Disease Associations

Tissue Specificity

Expressed in all tissues tested, with a predominance in brain, skeletal muscle, heart, and other tissues containing smooth muscle. In the heart, expression is restricted to the cardiomyocytes in the ventricle and atrium. {ECO:0000269PubMed:15598648}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017020	myosin phosphatase regulator activity
GO:0031072	heat shock protein binding
GO:0046872	metal ion binding

Biological Process

GO:0002028	regulation of sodium ion transport
GO:0006468	protein phosphorylation
GO:0006874	cellular calcium ion homeostasis
GO:0006998	nuclear envelope organization
GO:0008016	regulation of heart contraction
GO:0010657	muscle cell apoptotic process
GO:0010830	regulation of myotube differentiation
GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling
GO:0014853	regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction
GO:0050790	regulation of catalytic activity
GO:0051823	regulation of synapse structural plasticity

Cellular Component

GO:0005640	nuclear outer membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031307	integral component of mitochondrial outer membrane
GO:0031965	nuclear membrane
GO:0033017	sarcoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

MGI:94906

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR014930 Myotonic dystrophy protein kinase, coiled coil
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF08826
PF00433

PRINTS

PR00109

PIRSF

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt