InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ascc3

Summary

InnateDB Protein

IDBP-149565.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ascc3

Protein Name

activating signal cointegrator 1 complex subunit 3

Synonyms

ASC1p200; B630009I04Rik; BC023451; D430001L07Rik; D630041L21; Helic1; RNAH;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036726

InnateDB Gene

IDBG-149559 (Ascc3)

Protein Structure

UniProt Annotation

Function

3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0043140	ATP-dependent 3'-5' DNA helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006307	DNA dealkylation involved in DNA repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008283	cell proliferation
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1925237

InterPro

IPR001650 Helicase, C-terminal
IPR003593 AAA+ ATPase domain
IPR004179 Sec63 domain
IPR006935 Helicase/UvrB domain
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF02889
PF04851
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00382
SM00611
SM00973
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

E9PZJ8