Version 5.4
Mus musculus Gene: Ascc3
Summary
InnateDB Gene IDBG-149559.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ascc3
Gene Name activating signal cointegrator 1 complex subunit 3
Synonyms ASC1p200; B630009I04Rik; BC023451; D430001L07Rik; D630041L21; Helic1; RNAH
Species Mus musculus
Ensembl Gene ENSMUSG00000038774
Encoded Proteins
IDBP-149565
activating signal cointegrator 1 complex subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23781071
[Homo sapiens] ASCC3 inhibits IFN-signalling to dampen antiviral innate immunity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112249:
This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:50592669-50851202
Strand Forward strand
Band B3
Transcripts
ENSMUST00000035606 ENSMUSP00000036726
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0043140 ATP-dependent 3'-5' DNA helicase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006307 DNA dealkylation involved in DNA repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008283 cell proliferation
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112249
View Gene Order
ENSBTAG00000020482
Not yet available
Cross-References
SwissProt E9PZJ8
TrEMBL
UniProt Splice Variant
Entrez Gene 77987
UniGene Mm.222497
RefSeq NM_198007 XM_006512923
OMIM
CCDS CCDS48555
HPRD
IMGT
MGI ID MGI:1925237
MGI Symbol Ascc3
EMBL AC137877 AC153529 AC159114 AK021027 AK052745 BC032189 BC059917
GenPept AAH32189 AAH59917 BAC25644 BAC35127
RNA Seq Atlas 77987

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca