InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptpn3

Summary

InnateDB Protein

IDBP-149634.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpn3

Protein Name

protein tyrosine phosphatase, non-receptor type 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075063

InnateDB Gene

IDBG-149658 (Ptpn3)

Protein Structure

UniProt Annotation

Function

May act at junctions between the membrane and the cytoskeleton. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0051117	ATPase binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0045930	negative regulation of mitotic cell cycle
GO:0051045	negative regulation of membrane protein ectodomain proteolysis
GO:0097421	liver regeneration

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0009898	cytoplasmic side of plasma membrane
GO:0019898	extrinsic component of membrane

Protein Structure and Domains

PDB ID

MGI:105307

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000299 FERM domain
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR000798 Ezrin/radixin/moesin like
IPR001478 PDZ domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR012151 Protein-tyrosine phosphatase, non-receptor type-3, -4
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029021 Protein-tyrosine phosphatase-like
IPR029071 Ubiquitin-related domain

PFAM