InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptpn3

Summary

InnateDB Gene

IDBG-149658.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpn3

Gene Name

protein tyrosine phosphatase, non-receptor type 3

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038764

Encoded Proteins

IDBP-149634

protein tyrosine phosphatase, non-receptor type 3

IDBP-539550

protein tyrosine phosphatase, non-receptor type 3

IDBP-531732

protein tyrosine phosphatase, non-receptor type 3

IDBP-537650

protein tyrosine phosphatase, non-receptor type 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070159:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:57190841-57301837

Strand

Reverse strand

Band

Transcripts

ENSMUST00000075637	ENSMUSP00000075063
ENSMUST00000123664
ENSMUST00000153926	ENSMUSP00000122490
ENSMUST00000150445
ENSMUST00000130900	ENSMUSP00000114805
ENSMUST00000151964	ENSMUSP00000120111

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0051117	ATPase binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0045930	negative regulation of mitotic cell cycle
GO:0051045	negative regulation of membrane protein ectodomain proteolysis
GO:0097421	liver regeneration

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0009898	cytoplasmic side of plasma membrane
GO:0019898	extrinsic component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000070159

View Gene Order

ENSBTAG00000018841

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_11

TCR pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

A2ALK8

TrEMBL

A2ALK9 A2ALL0 A2ALL1 Q14BS5 Q62133

UniProt Splice Variant

Entrez Gene

545622

UniGene

Mm.246552

RefSeq

NM_011207 XM_006538095 XM_006538096 XM_006538097 XM_006538098 XM_006538099 XM_006538100 XM_006538101

OMIM

CCDS

CCDS51181

HPRD

IMGT

MGI ID

MGI:105307

MGI Symbol

Ptpn3

EMBL

AL805921 BC115634 BC115635 X82561

GenPept

AAI15635 AAI15636 CAA57908 CAM19971

RNA Seq Atlas

545622