InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gipr

Summary

InnateDB Protein

IDBP-149668.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gipr

Protein Name

gastric inhibitory polypeptide receptor

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092384

InnateDB Gene

IDBG-149666 (Gipr)

Protein Structure

UniProt Annotation

Function

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0016519	gastric inhibitory peptide receptor activity
GO:0017046	peptide hormone binding

Biological Process

GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0009749	response to glucose
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031018	endocrine pancreas development
GO:0032024	positive regulation of insulin secretion
GO:0038192	gastric inhibitory peptide signaling pathway
GO:0048678	response to axon injury
GO:0051592	response to calcium ion
GO:0070542	response to fatty acid

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1352753

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001749 GPCR, family 2, gastric inhibitory polypeptide receptor
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR01129

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt