InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gipr

Summary

InnateDB Gene

IDBG-149666.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gipr

Gene Name

gastric inhibitory polypeptide receptor

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030406

Encoded Proteins

IDBP-149668

gastric inhibitory polypeptide receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000010310:
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:19157125-19166127

Strand

Reverse strand

Band

Transcripts

ENSMUST00000094790

ENSMUSP00000092384

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0016519	gastric inhibitory peptide receptor activity
GO:0017046	peptide hormone binding

Biological Process

GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0009749	response to glucose
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031018	endocrine pancreas development
GO:0032024	positive regulation of insulin secretion
GO:0038192	gastric inhibitory peptide signaling pathway
GO:0048678	response to axon injury
GO:0051592	response to calcium ion
GO:0070542	response to fatty acid