InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Egfl7

Summary

InnateDB Protein

IDBP-149725.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Egfl7

Protein Name

EGF-like domain 7

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097863

InnateDB Gene

IDBG-149717 (Egfl7)

Protein Structure

UniProt Annotation

Function

Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis. {ECO:0000269PubMed:14592969, ECO:0000269PubMed:15085134}.

Subcellular Localization

Secreted, extracellular space {ECO:0000269PubMed:14592969, ECO:0000269PubMed:15162510}.

Disease Associations

Tissue Specificity

Expressed specifically by endothelial cells of the highly vascularized organs heart, lung and kidney. {ECO:0000269PubMed:14592969, ECO:0000269PubMed:15162510}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001568	blood vessel development
GO:0001570	vasculogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0007155	cell adhesion
GO:0030334	regulation of cell migration
GO:0030336	negative regulation of cell migration
GO:0045746	negative regulation of Notch signaling pathway