Version 5.4
Mus musculus Protein: Mlf1
Summary
InnateDB Protein IDBP-150130.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mlf1
Protein Name myeloid leukemia factor 1
Synonyms HLS7;
Species Mus musculus
Ensembl Protein ENSMUSP00000077072
InnateDB Gene IDBG-150128 (Mlf1)
Protein Structure
UniProt Annotation
Function Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. {ECO:0000269PubMed:10523300, ECO:0000269PubMed:15122318}.
Subcellular Localization Cytoplasm. Nucleus. Note=In non- hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus.
Disease Associations
Tissue Specificity Highly expressed in skeletal muscle, heart, testis. Also found in lung, but not in spleen, thymus, bone marrow, liver and kidney. {ECO:0000269PubMed:10393836}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0002318 myeloid progenitor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0007050 cell cycle arrest
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1341819
InterPro IPR019376 Myeloid leukemia factor
PFAM PF10248
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QWV4
PhosphoSite PhosphoSite-Q9QWV4
TrEMBL Q3V042
UniProt Splice Variant
Entrez Gene 17349
UniGene Mm.467955
RefSeq NP_034931
MGI ID
MGI Symbol Mlf1
OMIM
CCDS CCDS17396
HPRD
IMGT
EMBL AF009515 AF100171 AK133448 CH466547
GenPept AAC17946 AAD02876 BAE21663 EDL15522

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca