Version 5.4
Mus musculus Gene: Mlf1
Summary
InnateDB Gene IDBG-150128.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mlf1
Gene Name myeloid leukemia factor 1
Synonyms HLS7
Species Mus musculus
Ensembl Gene ENSMUSG00000048416
Encoded Proteins
IDBP-150130
myeloid leukemia factor 1
IDBP-150132
myeloid leukemia factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178053:
This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:67374097-67400003
Strand Forward strand
Band E1
Transcripts
ENSMUST00000077916 ENSMUSP00000077072
ENSMUST00000061322 ENSMUSP00000058596
ENSMUST00000142538
ENSMUST00000126628
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0002318 myeloid progenitor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0007050 cell cycle arrest
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000178053
View Gene Order
ENSBTAG00000004126
Not yet available
Cross-References
SwissProt Q9QWV4
TrEMBL Q3V042
UniProt Splice Variant
Entrez Gene 17349
UniGene Mm.10414 Mm.467955
RefSeq NM_010801 NM_001039543
OMIM
CCDS CCDS17396 CCDS17395
HPRD
IMGT
MGI ID MGI:1341819
MGI Symbol Mlf1
EMBL AF009515 AF100171 AK133448 CH466547
GenPept AAC17946 AAD02876 BAE21663 EDL15522
RNA Seq Atlas 17349

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca