Version 5.4
Mus musculus Protein: Musk
Summary
InnateDB Protein IDBP-150214.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Musk
Protein Name muscle, skeletal, receptor tyrosine kinase
Synonyms Mdk4; Mlk; Nsk1; Nsk2; Nsk3;
Species Mus musculus
Ensembl Protein ENSMUSP00000095667
InnateDB Gene IDBG-150212 (Musk)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007528 neuromuscular junction development
GO:0008582 regulation of synaptic growth at neuromuscular junction
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0043113 receptor clustering
GO:0043525 positive regulation of neuron apoptotic process
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0031594 neuromuscular junction
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID MGI:103581
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR020067 Frizzled domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF07679
PF07686
PF00047
PF01392
PRINTS PR00109
PIRSF
SMART SM00220
SM00408
SM00409
SM00063
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q8K3G6
UniProt Splice Variant
Entrez Gene 18198
UniGene Mm.16148
RefSeq
MGI ID
MGI Symbol Musk
OMIM
CCDS
HPRD
IMGT
EMBL AL805969 AL807748 AY114512
GenPept AAM66750

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca