InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Musk

Summary

InnateDB Protein

IDBP-150216.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Musk

Protein Name

muscle, skeletal, receptor tyrosine kinase

Synonyms

Mdk4; Mlk; Nsk1; Nsk2; Nsk3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095665

InnateDB Gene

IDBG-150212 (Musk)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007528	neuromuscular junction development
GO:0008582	regulation of synaptic growth at neuromuscular junction
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043113	receptor clustering
GO:0043525	positive regulation of neuron apoptotic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0031594	neuromuscular junction
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:103581

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR020067 Frizzled domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF07679
PF07686
PF00047
PF01392

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00408
SM00409
SM00063
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt