Version 5.4
Mus musculus Protein: Mtus1
Summary
InnateDB Protein IDBP-150354.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mtus1
Protein Name mitochondrial tumor suppressor 1
Synonyms AI481402; ATBP135; Atip1; B430010I23Rik; B430305I03Rik; C85752; Cctsg1-440; MD44; mKIAA1288; MTSG1;
Species Mus musculus
Ensembl Protein ENSMUSP00000053554
InnateDB Gene IDBG-150350 (Mtus1)
Protein Structure
UniProt Annotation
Function Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. {ECO:0000269PubMed:15123706, ECO:0000269PubMed:15539617, ECO:0000269PubMed:17068200}.
Subcellular Localization Mitochondrion {ECO:0000250}. Golgi apparatus. Cell membrane. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II.
Disease Associations
Tissue Specificity Ubiquitously expressed, with highest levels in uterus and adrenal gland. {ECO:0000269PubMed:15539617}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007049 cell cycle
GO:0010758 regulation of macrophage chemotaxis
GO:0071375 cellular response to peptide hormone stimulus
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:2142572
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5HZI1
PhosphoSite PhosphoSite-Q5HZI1
TrEMBL Q8K0Q3
UniProt Splice Variant
Entrez Gene 102103
UniGene Mm.475369
RefSeq NP_001005865
MGI ID
MGI Symbol Mtus1
OMIM
CCDS CCDS40330
HPRD
IMGT
EMBL AF173380 AF493235 AK030510 AK031693 AK129324 AK143781 AY246699 AY626781 AY626782 AY626783 BC030860 BC041777 BC042206 BC043321 BC089009
GenPept AAD49746 AAH30860 AAH41777 AAH42206 AAH43321 AAH89009 AAO88908 AAQ06609 AAT45892 AAT45893 AAT45894 BAC26996 BAC27517 BAC98134 BAE25537

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca