InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD4

Summary

InnateDB Protein

IDBP-15036.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD4

Protein Name

CD4 molecule

Synonyms

CD4mut;

Species

Homo sapiens

Ensembl Protein

ENSP00000011653

InnateDB Gene

IDBG-15034 (CD4)

Protein Structure

UniProt Annotation

Function

Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12517957}; Single-pass type I membrane protein {ECO:0000269PubMed:12517957}. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	89 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0015026	coreceptor activity
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0042289	MHC class II protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001816	cytokine production
GO:0006948	induction by virus of host cell-cell fusion
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0016032	viral process
GO:0030217	T cell differentiation
GO:0030260	entry into host cell
GO:0031295	T cell costimulation
GO:0032507	maintenance of protein location in cell
GO:0042110	T cell activation
GO:0045058	T cell selection
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response
GO:0045234	protein palmitoleylation
GO:0045860	positive regulation of protein kinase activity
GO:0050690	regulation of defense response to virus by virus
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829	defense response to Gram-negative bacterium
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050852	T cell receptor signaling pathway
GO:0050863	regulation of T cell activation
GO:0050870	positive regulation of T cell activation

Cellular Component

GO:0005769	early endosome
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0042101	T cell receptor complex
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR000973 T-cell surface antigen CD4
IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR008424 Immunoglobulin C2-set
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR015274 CD4, extracellular
IPR021963 T cell CD4 receptor C-terminal region
IPR024303 Natural killer cell receptor 2B4 immunoglobulin domain

PFAM