InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD4

Summary

InnateDB Gene

IDBG-15034.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD4

Gene Name

CD4 molecule

Synonyms

CD4mut

Species

Homo sapiens

Ensembl Gene

ENSG00000010610

Encoded Proteins

IDBP-15036

CD4 molecule

IDBP-603821

CD4 molecule

IDBP-600064

CD4 molecule

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:6786858-6820808

Strand

Forward strand

Band

p13.31

Transcripts

ENST00000011653	ENSP00000011653
ENST00000437800
ENST00000535707
ENST00000536610
ENST00000544344
ENST00000541982	ENSP00000445167
ENST00000538827
ENST00000535466
ENST00000536590
ENST00000539492	ENSP00000440720
ENST00000536563
ENST00000543755

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	89 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0015026	coreceptor activity
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0042289	MHC class II protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001816	cytokine production
GO:0006948	induction by virus of host cell-cell fusion
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0016032	viral process
GO:0030217	T cell differentiation
GO:0030260	entry into host cell
GO:0031295	T cell costimulation
GO:0032507	maintenance of protein location in cell
GO:0042110	T cell activation
GO:0045058	T cell selection
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response
GO:0045234	protein palmitoleylation
GO:0045860	positive regulation of protein kinase activity
GO:0050690	regulation of defense response to virus by virus
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829	defense response to Gram-negative bacterium
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050852	T cell receptor signaling pathway
GO:0050863	regulation of T cell activation
GO:0050870	positive regulation of T cell activation

Cellular Component

GO:0005769	early endosome
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0042101	T cell receptor complex
GO:0045121	membrane raft