InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Opn4

Summary

InnateDB Protein

IDBP-150390.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Opn4

Protein Name

opsin 4 (melanopsin)

Synonyms

1110007J02Rik; Gm533;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022331

InnateDB Gene

IDBG-150388 (Opn4)

Protein Structure

UniProt Annotation

Function

Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all- trans retinal back to 11-cis retinal. {ECO:0000269PubMed:10632589, ECO:0000269PubMed:12808468, ECO:0000269PubMed:19793992}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19793992}; Multi-pass membrane protein {ECO:0000269PubMed:19793992}. Note=Found in soma, dendrites and proximal part of axons of certain retinal ganglion cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina. Isoform 2 is about 40 times more abundant than isoform 1 in the retina. Isoform 1 is observed with processes in the outer strata of inner plexiform layer (IPL) close to the inner nuclear layer (INL) or is found to be bistratified with processes located both in the inner (ON) or outer (OFF) layers of the IPL. A second population of isoform 1 is identified in processes which are confined to the inner layer of the IPL near to the ganglion cell layer (GCL). Isoform 2 is involved in processes localized to the outer IPL or is bistratified with processes in both the inner and outer layers of the IPL. Isoform 2 is absent in the processes confined only to the inner layer of the IPL. {ECO:0000269PubMed:10632589, ECO:0000269PubMed:19793992}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005502	11-cis retinal binding
GO:0008020	G-protein coupled photoreceptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0016056	rhodopsin mediated signaling pathway
GO:0018298	protein-chromophore linkage
GO:0042752	regulation of circadian rhythm
GO:0048511	rhythmic process

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1353425

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001760 Opsin
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10323
PF10328

PRINTS

PR00237
PR00238

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QXZ9