InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Opn4

Summary

InnateDB Gene

IDBG-150388.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Opn4

Gene Name

opsin 4 (melanopsin)

Synonyms

1110007J02Rik; Gm533

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021799

Encoded Proteins

IDBP-150390

opsin 4 (melanopsin)

IDBP-625026

opsin 4 (melanopsin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122375:
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:34590618-34600142

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022331	ENSMUSP00000022331
ENSMUST00000168444	ENSMUSP00000126136

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005502	11-cis retinal binding
GO:0008020	G-protein coupled photoreceptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0016056	rhodopsin mediated signaling pathway
GO:0018298	protein-chromophore linkage
GO:0042752	regulation of circadian rhythm
GO:0048511	rhythmic process