InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde1c

Summary

InnateDB Protein

IDBP-150474.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde1c

Protein Name

phosphodiesterase 1C

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046601

InnateDB Gene

IDBG-150470 (Pde1c)

Protein Structure

UniProt Annotation

Function

Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.

Subcellular Localization

Disease Associations

Tissue Specificity

Isoform 1 is highly expressed in testis. Isoform 2 is highly expressed in heart and testis, and detected at lower levels in olfactory epithelium and cerebellum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005516	calmodulin binding
GO:0046872	metal ion binding
GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0007165	signal transduction
GO:0007608	sensory perception of smell
GO:0008152	metabolic process
GO:0051592	response to calcium ion

Cellular Component

GO:0005929

cilium

Protein Structure and Domains

PDB ID

MGI:108413

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR013706 3\'5\'-cyclic nucleotide phosphodiesterase N-terminal
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233
PF08499

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt