Version 5.4
Mus musculus Protein: Ckm
Summary
InnateDB Protein IDBP-150646.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ckm
Protein Name creatine kinase, muscle
Synonyms Ckmm; M-CK; MCK;
Species Mus musculus
Ensembl Protein ENSMUSP00000003643
InnateDB Gene IDBG-150644 (Ckm)
Protein Structure
UniProt Annotation
Function Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 10 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004111 creatine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006603 phosphocreatine metabolic process
GO:0016310 phosphorylation
GO:0046314 phosphocreatine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:88413
InterPro IPR022413 ATP:guanido phosphotransferase, N-terminal
IPR022414 ATP:guanido phosphotransferase, catalytic domain
PFAM PF02807
PF00217
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07310
PhosphoSite PhosphoSite-P07310
TrEMBL A2RTA0
UniProt Splice Variant
Entrez Gene 12715
UniGene Mm.2375
RefSeq NP_031736
MGI ID
MGI Symbol Ckm
OMIM
CCDS CCDS20902
HPRD
IMGT
EMBL BC132424 BC132426 CH466639 X03233
GenPept AAI32425 AAI32427 CAA26979 EDL23143

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca