InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Camk2a

Summary

InnateDB Protein

IDBP-150659.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Camk2a

Protein Name

calcium/calmodulin-dependent protein kinase II alpha

Synonyms

CaMKII; mKIAA0968; R74975;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099952

InnateDB Gene

IDBG-150657 (Camk2a)

Protein Structure

UniProt Annotation

Function

CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform Alpha KAP: Cytoplasm {ECO:0000305}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Postsynaptic lipid rafts. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform Alpha CaMKII is expressed in brain while isoform Alpha KAP is expressed in skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0035254	glutamate receptor binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006816	calcium ion transport
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation
GO:0046928	regulation of neurotransmitter secretion
GO:0048168	regulation of neuronal synaptic plasticity
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005954	calcium- and calmodulin-dependent protein kinase complex
GO:0030054	cell junction
GO:0042734	presynaptic membrane

Protein Structure and Domains

PDB ID

MGI:88256

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF08332

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt