InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Camk2a

Summary

InnateDB Protein

IDBP-150661.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Camk2a

Protein Name

calcium/calmodulin-dependent protein kinase II alpha

Synonyms

CaMKII; mKIAA0968; R74975;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025519

InnateDB Gene

IDBG-150657 (Camk2a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0035254	glutamate receptor binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006816	calcium ion transport
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation
GO:0046928	regulation of neurotransmitter secretion
GO:0048168	regulation of neuronal synaptic plasticity

Cellular Component

Protein Structure and Domains

PDB ID

MGI:88256

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF08332

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt