InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il12a

Summary

InnateDB Protein

IDBP-150827.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il12a

Protein Name

interleukin 12a

Synonyms

Il-12a; IL-12p35; Ll12a; p35;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029345

InnateDB Gene

IDBG-150825 (Il12a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	3 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005143	interleukin-12 receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042163	interleukin-12 beta subunit binding
GO:0045513	interleukin-27 binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0006955	immune response
GO:0007050	cell cycle arrest
GO:0009615	response to virus
GO:0010224	response to UV-B
GO:0016477	cell migration
GO:0032496	response to lipopolysaccharide
GO:0032700	negative regulation of interleukin-17 production
GO:0032729	positive regulation of interferon-gamma production
GO:0032816	positive regulation of natural killer cell activation
GO:0032946	positive regulation of mononuclear cell proliferation
GO:0034393	positive regulation of smooth muscle cell apoptotic process
GO:0042102	positive regulation of T cell proliferation
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042832	defense response to protozoan
GO:0045087	innate immune response (InnateDB)
GO:0045582	positive regulation of T cell differentiation
GO:0045785	positive regulation of cell adhesion
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050671	positive regulation of lymphocyte proliferation
GO:0050830	defense response to Gram-positive bacterium
GO:0051135	positive regulation of NK T cell activation
GO:0097191	extrinsic apoptotic signaling pathway