InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ift80

Summary

InnateDB Protein

IDBP-150943.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ift80

Protein Name

intraflagellar transport 80 homolog (Chlamydomonas)

Synonyms

4921524P20Rik; mKIAA1374; Wdr56;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029347

InnateDB Gene

IDBG-150941 (Ift80)

Protein Structure

UniProt Annotation

Function

Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Note=Basal body and ciliary axoneme in the chondrocytic ATDC-5 cell line.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0002062	chondrocyte differentiation
GO:0007224	smoothened signaling pathway
GO:0042073	intraciliary transport
GO:0042384	cilium assembly
GO:0045880	positive regulation of smoothened signaling pathway
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060271	cilium morphogenesis
GO:0060349	bone morphogenesis
GO:2000051	negative regulation of non-canonical Wnt signaling pathway