Version 5.4
Mus musculus Gene: Ift80
Summary
InnateDB Gene IDBG-150941.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ift80
Gene Name intraflagellar transport 80
Synonyms 4921524P20Rik; mKIAA1374; Wdr56
Species Mus musculus
Ensembl Gene ENSMUSG00000027778
Encoded Proteins
IDBP-150943
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-265874
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-536997
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-532946
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-627402
intraflagellar transport 80 homolog (Chlamydomonas)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068885:
The protein encoded by this gene is part of the intraflagellar transport complex B and is necessary for the function of motile and sensory cilia. Defects in this gene are a cause of asphyxiating thoracic dystrophy 2 (ATD2). Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:68892499-69004570
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000029347 ENSMUSP00000029347
ENSMUST00000107812 ENSMUSP00000103442
ENSMUST00000136448
ENSMUST00000136176
ENSMUST00000152502
ENSMUST00000154741 ENSMUSP00000118406
ENSMUST00000148031 ENSMUSP00000122919
ENSMUST00000169064 ENSMUSP00000133263
ENSMUST00000176189
ENSMUST00000176754
ENSMUST00000176135
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0002062 chondrocyte differentiation
GO:0007224 smoothened signaling pathway
GO:0042073 intraciliary transport
GO:0042384 cilium assembly
GO:0045880 positive regulation of smoothened signaling pathway
GO:0050680 negative regulation of epithelial cell proliferation
GO:0060271 cilium morphogenesis
GO:0060349 bone morphogenesis
GO:2000051 negative regulation of non-canonical Wnt signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005929 cilium
GO:0030992 intraciliary transport particle B
GO:0036064 ciliary basal body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000068885
View Gene Order
ENSBTAG00000031572
Not yet available
Cross-References
SwissProt Q8K057
TrEMBL D3YWI8 D3Z157
UniProt Splice Variant
Entrez Gene 68259
UniGene Mm.389451 Mm.490774
RefSeq XM_006501968 NM_026641 XM_006501966
OMIM
CCDS CCDS38451
HPRD
IMGT
MGI ID MGI:1915509
MGI Symbol Ift80
EMBL AC115062 AC122876 AK042231 AK129339 BC013814 BC034101
GenPept AAH13814 AAH34101 BAC31200 BAC98149
RNA Seq Atlas 68259

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca