InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vav2

Summary

InnateDB Protein

IDBP-151032.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vav2

Protein Name

vav 2 oncogene

Synonyms

2810040F13Rik; AI847175;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062782

InnateDB Gene

IDBG-151026 (Vav2)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. {ECO:0000269PubMed:16782872}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0007264	small GTPase mediated signal transduction
GO:0010468	regulation of gene expression
GO:0016477	cell migration
GO:0030031	cell projection assembly
GO:0030032	lamellipodium assembly
GO:0030193	regulation of blood coagulation
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043087	regulation of GTPase activity
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:102718

InterPro

IPR000219 Dbl homology (DH) domain
IPR000980 SH2 domain
IPR001452 SH3 domain
IPR001715 Calponin homology domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR011511 Variant SH3 domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM