Version 5.4
Mus musculus Protein: Cdhr1
Summary
InnateDB Protein IDBP-151056.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdhr1
Protein Name cadherin-related family member 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000022337
InnateDB Gene IDBG-151054 (Cdhr1)
Protein Structure
UniProt Annotation
Function Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Localized at the junction between the inner and outer segments of rod and cone photoreceptors cells. Confined to the base of the OS. Localized on the edges of nascent evaginating disks on the side of the OS opposite the connecting cilium. Expressed at postnatal day 2 at the apical tip of the rod photoreceptor cells, the site of the developing OS. Colocalized with rhodopsin between postnatal days 2 and 9 at the base of the growing OS region. {ECO:0000269PubMed:11738025, ECO:0000269PubMed:15284225}.
Disease Associations
Tissue Specificity Expressed in cone and rod photoreceptor cells (at protein level). Expressed in photoreceptor cells of the outer nuclear layer of the retina. Expressed in mitral and tufted cells in the olfactory bulb. {ECO:0000269PubMed:11738025, ECO:0000269PubMed:15284225, ECO:0000269PubMed:16106355}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0009987 cellular process
GO:0045494 photoreceptor cell maintenance
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0042622 photoreceptor outer segment membrane
Protein Structure and Domains
PDB ID MGI:2157782
InterPro IPR002126 Cadherin
IPR015919 Cadherin-like
PFAM PF00028
PRINTS PR00205
PIRSF
SMART SM00112
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VHP6
PhosphoSite PhosphoSite-Q8VHP6
TrEMBL
UniProt Splice Variant
Entrez Gene 170677
UniGene Mm.474851
RefSeq NP_570948
MGI ID
MGI Symbol Cdhr1
OMIM
CCDS CCDS26952
HPRD
IMGT
EMBL AB093300 AF426393 BC042454 BC058270
GenPept AAH42454 AAH58270 AAL65140 BAC41482

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca