Version 5.4
Mus musculus Protein: Gnptg
Summary
InnateDB Protein IDBP-151119.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gnptg
Protein Name N-acetylglucosamine-1-phosphotransferase, gamma subunit
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000042073
InnateDB Gene IDBG-151117 (Gnptg)
Protein Structure
UniProt Annotation
Function Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine- 1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors. {ECO:0000269PubMed:15716021}.
Subcellular Localization Secreted. Golgi apparatus.
Disease Associations
Tissue Specificity Widely expressed. Highly expressed in the liver, intestine, brain, thymus, testis and ovary. {ECO:0000269PubMed:15716021}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0042803 protein homodimerization activity
Biological Process
GO:0016256 N-glycan processing to lysosome
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID MGI:2147006
InterPro IPR009011 Mannose-6-phosphate receptor binding domain
IPR012913 Glucosidase II beta subunit-like
PFAM PF07915
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6S5C2
PhosphoSite PhosphoSite-Q6S5C2
TrEMBL Q5UJ03
UniProt Splice Variant
Entrez Gene 214505
UniGene Mm.38607
RefSeq NP_766117
MGI ID
MGI Symbol Gnptg
OMIM
CCDS CCDS28511
HPRD
IMGT
EMBL AK078230 AY465529 AY724414 AY724415 AY724416 AY724417 AY724418 AY724419 AY724420 AY724421 AY724422 AY724423 AY724424 AY724425 AY724426 AY724427 AY724428 AY724429 AY724430 AY724431 AY724432 AY724433 AY724434 AY724435 BC055872
GenPept AAH55872 AAR19081 AAV32794 AAV32795 AAV32796 AAV32797 AAV32798 AAV32799 AAV32800 AAV32801 AAV32802 AAV32803 AAV32804 AAV32805 AAV32806 AAV32807 AAV32808 AAV32809 AAV32810 AAV32811 AAV32812 AAV32813 AAV32814 AAV32815 BAC37183

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca