Version 5.4
Mus musculus Gene: Gnptg
Summary
InnateDB Gene IDBG-151117.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gnptg
Gene Name N-acetylglucosamine-1-phosphotransferase, gamma subunit
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000035521
Encoded Proteins
IDBP-151119
N-acetylglucosamine-1-phosphotransferase, gamma subunit
IDBP-250256
N-acetylglucosamine-1-phosphotransferase, gamma subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090581:
This gene encodes the gamma sunbunit of the N-acetylglucosamine-1-phosphotransferase complex. This hexameric complex, composed of alpha, beta and gamma subunits, catalyzes the first step in synthesis of a mannose 6-phosphate lysosomal recognition marker. This enzyme complex is necessary for targeting of lysosomal hydrolases to the lysosome. Mutations in the gene encoding the gamma subunit have been associated with mucolipidosis IIIC, also known as mucolipidosis III gamma.[provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:25233331-25240124
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000038973 ENSMUSP00000042073
ENSMUST00000115154 ENSMUSP00000110807
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0016256 N-glycan processing to lysosome
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000090581
View Gene Order
ENSBTAG00000014118
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt Q6S5C2
TrEMBL
UniProt Splice Variant
Entrez Gene 214505
UniGene Mm.38607
RefSeq XM_006543355 XM_006543356 NM_172529
OMIM
CCDS CCDS28511
HPRD
IMGT
MGI ID MGI:2147006
MGI Symbol Gnptg
EMBL AK078230 AY465529 BC055872
GenPept AAH55872 AAR19081 BAC37183
RNA Seq Atlas 102641579 102641602 214505

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca