InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc40a1

Summary

InnateDB Protein

IDBP-151282.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc40a1

Protein Name

solute carrier family 40 (iron-regulated transporter), member 1

Synonyms

Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm; Slc11a3; Slc39a1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027137

InnateDB Gene

IDBG-151280 (Slc40a1)

Protein Structure

UniProt Annotation

Function

May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Note=Localized to the basolateral membrane of polarized epithelial cells.

Disease Associations

Tissue Specificity

High expression in spleen, liver, kidney, heart and duodenum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005381	iron ion transmembrane transporter activity
GO:0005515	protein binding

Biological Process

GO:0002260	lymphocyte homeostasis
GO:0003158	endothelium development
GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron
GO:0034755	iron ion transmembrane transport
GO:0043066	negative regulation of apoptotic process
GO:0048536	spleen development
GO:0060345	spleen trabecula formation
GO:0060586	multicellular organismal iron ion homeostasis

Cellular Component

GO:0005622	intracellular
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane