InnateDB Protein
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IDBP-151296.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ppm1k
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Protein Name
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protein phosphatase 1K (PP2C domain containing)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000041395
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InnateDB Gene
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IDBG-151294 (Ppm1k)
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Protein Structure
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Function |
Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. {ECO:0000269PubMed:17374715}.
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Subcellular Localization |
Mitochondrion matrix {ECO:0000269PubMed:17374715}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in the heart, kidney, brain and liver and to a lesser extent in testis, lung, spleen and adipose tissue. Very low amount in muscle (at protein level). Also expressed in the thymus (at protein level) and the diaphragm. Significantly reduced in hypertrophied hearts. {ECO:0000269PubMed:17336929, ECO:0000269PubMed:17374715}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2442111
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InterPro |
IPR001932
Protein phosphatase 2C (PP2C)-like domain
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PFAM |
PF00481
PF07228
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PRINTS |
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PIRSF |
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SMART |
SM00331
SM00332
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BXN7
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PhosphoSite |
PhosphoSite-Q8BXN7
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TrEMBL |
B9EHW0
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UniProt Splice Variant |
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Entrez Gene |
243382
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UniGene |
Mm.489618
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RefSeq |
NP_780732
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MGI ID |
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MGI Symbol |
Ppm1k
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OMIM |
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CCDS |
CCDS20183
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HPRD |
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IMGT |
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EMBL |
AK044610
BC092238
BC138473
BC138474
CH466643
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GenPept |
AAH92238
AAI38474
AAI38475
BAC32001
EDL04740
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