Version 5.4
Mus musculus Protein: Frg1
Summary
InnateDB Protein IDBP-151310.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Frg1
Protein Name FSHD region gene 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000033999
InnateDB Gene IDBG-151308 (Frg1)
Protein Structure
UniProt Annotation
Function Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase SUV420H1. {ECO:0000269PubMed:23720823}.
Subcellular Localization Nucleus, Cajal body {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm. Cytoplasm, myofibril, sarcomere, Z line. Note=Localization changes during myogenesis from mainly cytoplasmic in undifferentiated myoblasts, to strongly nucleolar in early myotubes and back to cytoplasmic 5 days post- differentiation. Localized at the Z-line in the sarcomere of matured myotubes 8 days post-differentiation.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030674 protein binding, bridging
GO:0044822 poly(A) RNA binding
GO:0051015 actin filament binding
Biological Process
GO:0006364 rRNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID MGI:893597
InterPro IPR008999 Actin cross-linking
IPR010414 FRG1-like
IPR022768 Fascin domain
PFAM PF06229
PF06268
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P97376
PhosphoSite PhosphoSite-P97376
TrEMBL Q78P92
UniProt Splice Variant
Entrez Gene 14300
UniGene
RefSeq NP_038550
MGI ID 2YUG
MGI Symbol Frg1
OMIM
CCDS CCDS22263
HPRD
IMGT
EMBL AK077107 AK079229 AY028080 BC002027 CH466554 U62105
GenPept AAB39540 AAH02027 AAK21978 BAC36616 BAC37582 EDL35522

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca