Mus musculus Protein: Relb | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-151423.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Relb | ||||||||||||||||||||||
Protein Name | avian reticuloendotheliosis viral (v-rel) oncogene related B | ||||||||||||||||||||||
Synonyms | shep; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000092355 | ||||||||||||||||||||||
InnateDB Gene | IDBG-151419 (Relb) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. {ECO:0000250, ECO:0000269PubMed:22565310, ECO:0000269PubMed:22894897}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with NEK6 in the centrosome. {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed in intestine, thymus and spleen. Undetectable in liver, bome marrow, kidney and testis. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:103289 | ||||||||||||||||||||||
InterPro |
IPR000451
NF-kappa-B/Rel/Dorsal IPR002909 IPT domain IPR008967 p53-like transcription factor, DNA-binding IPR011539 Rel homology domain IPR014756 Immunoglobulin E-set |
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PFAM |
PF01833
PF00554 |
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PRINTS |
PR00057
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PIRSF | |||||||||||||||||||||||
SMART |
SM00429
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q04863 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q04863 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 19698 | ||||||||||||||||||||||
UniGene | Mm.1741 | ||||||||||||||||||||||
RefSeq | NP_033072 | ||||||||||||||||||||||
MGI ID | 4JHB | ||||||||||||||||||||||
MGI Symbol | Relb | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS39799 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AK146932 BC019765 BC117793 M83380 S56076 S76754 | ||||||||||||||||||||||
GenPept | AAA40041 AAB25493 AAB33259 AAH19765 AAI17794 BAE27543 | ||||||||||||||||||||||