InnateDB Protein
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IDBP-151439.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ppp1cb
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Protein Name
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protein phosphatase 1, catalytic subunit, beta isoform
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Synonyms
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1200010B19;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000015100
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InnateDB Gene
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IDBG-151435 (Ppp1cb)
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Protein Structure
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Function |
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. {ECO:0000269PubMed:21712997, ECO:0000269PubMed:21930935}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
55 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:104871
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InterPro |
IPR004843
Calcineurin-like phosphoesterase domain, apaH type
IPR006186
Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052
Metallo-dependent phosphatase-like
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PFAM |
PF00149
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PRINTS |
PR00114
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PIRSF |
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SMART |
SM00156
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TIGRFAMs |
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Modification |
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SwissProt |
P62141
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PhosphoSite |
PhosphoSite-P62141
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
19046
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UniGene |
Mm.456635
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RefSeq |
NP_766295
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MGI ID |
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MGI Symbol |
Ppp1cb
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OMIM |
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CCDS |
CCDS19193
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HPRD |
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IMGT |
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EMBL |
AK004686
AK088893
AK089067
AK147112
AK160743
AK166168
AK166623
AK168141
AK169379
AK171283
BC046832
M27073
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GenPept |
AAA37527
AAH46832
BAB23473
BAC40636
BAC40733
BAE27684
BAE35984
BAE38608
BAE38902
BAE40108
BAE41126
BAE42366
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