Mus musculus Gene: Ppp1cb | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-151435.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Ppp1cb | ||||||||||||||||||||||
Gene Name | protein phosphatase 1, catalytic subunit, beta isoform | ||||||||||||||||||||||
Synonyms | 1200010B19 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000014956 | ||||||||||||||||||||||
Encoded Proteins |
protein phosphatase 1, catalytic subunit, beta isoform
protein phosphatase 1, catalytic subunit, beta isoform
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213639:
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:32458974-32517433 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | B1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
Downregulation of TGF-beta receptor signaling pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Disease pathway
Loss of Function of SMAD4 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Cell Cycle pathway
Metabolism pathway
TGF-beta receptor signaling activates SMADs pathway
Metabolism of lipids and lipoproteins pathway
Loss of Function of TGFBR2 in Cancer pathway
Lipid digestion, mobilization, and transport pathway
Mitotic G2-G2/M phases pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
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KEGG |
Insulin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Long-term potentiation pathway
Focal adhesion pathway
Vascular smooth muscle contraction pathway
Oocyte meiosis pathway
mRNA surveillance pathway pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Regulation of PLK1 Activity at G2/M Transition pathway
Downregulation of TGF-beta receptor signaling pathway
TGF-beta receptor signaling activates SMADs pathway
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Metabolism of lipids and lipoproteins pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Cell Cycle pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
G2/M Transition pathway
TGFBR1 KD Mutants in Cancer pathway
Cell Cycle, Mitotic pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Mitotic G2-G2/M phases pathway
Metabolism pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Lipid digestion, mobilization, and transport pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Long-term potentiation pathway
Insulin signaling pathway pathway
Focal adhesion pathway
Vascular smooth muscle contraction pathway
Oocyte meiosis pathway
mRNA surveillance pathway pathway
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INOH | |||||||||||||||||||||||
PID NCI |
PLK1 signaling events
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Cross-References | |||||||||||||||||||||||
SwissProt | P62141 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 19046 | ||||||||||||||||||||||
UniGene | Mm.241931 Mm.418253 Mm.456635 | ||||||||||||||||||||||
RefSeq | NM_172707 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS19193 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:104871 | ||||||||||||||||||||||
MGI Symbol | Ppp1cb | ||||||||||||||||||||||
EMBL | AK004686 AK088893 AK089067 AK147112 AK160743 AK166168 AK166623 AK168141 AK169379 AK171283 BC046832 M27073 | ||||||||||||||||||||||
GenPept | AAA37527 AAH46832 BAB23473 BAC40636 BAC40733 BAE27684 BAE35984 BAE38608 BAE38902 BAE40108 BAE41126 BAE42366 | ||||||||||||||||||||||
RNA Seq Atlas | 19046 | ||||||||||||||||||||||