Version 5.4
Mus musculus Protein: Sptssb
Summary
InnateDB Protein IDBP-151771.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sptssb
Protein Name RIKEN cDNA 1110032A04 gene
Synonyms 1110032A04Rik; ADMP; Sssptb;
Species Mus musculus
Ensembl Protein ENSMUSP00000062794
InnateDB Gene IDBG-151769 (Sptssb)
Protein Structure
UniProt Annotation
Function Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expression is strong in hypogonadal (hpg) mouse prostate, weak in mature castrated mouse prostate and absent in normal intact or androgen-replaced hpg mouse prostates. {ECO:0000269PubMed:15777716}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004758 serine C-palmitoyltransferase activity
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0008150 biological_process
Cellular Component
GO:0016021 integral component of membrane
GO:0017059 serine C-palmitoyltransferase complex
Protein Structure and Domains
PDB ID MGI:1913433
InterPro IPR024512 Small subunit of serine palmitoyltransferase-like
PFAM PF11779
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q925E8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 66183
UniGene Mm.45481
RefSeq NP_598436
MGI ID
MGI Symbol Sptssb
OMIM
CCDS CCDS38453
HPRD
IMGT
EMBL AF365876 AK004017 AK009973 AK010117 BC022628
GenPept AAH22628 AAK53702 BAC25062 BAC25279 BAC25280

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca