InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aldh1a1

Summary

InnateDB Protein

IDBP-151902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh1a1

Protein Name

aldehyde dehydrogenase family 1, subfamily A1

Synonyms

Ahd-2; Ahd2; Aldh1; Aldh1a2; E1; Raldh1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084918

InnateDB Gene

IDBG-151900 (Aldh1a1)

Protein Structure

UniProt Annotation

Function

In addition to the activity on acetaldehyde and related substrates, is also involved in the oxidation of aldehydes derived from biogenic amines such as epinephrine and norepinephrine, as well as the aldehydes generated via lipid peroxidation. Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in the liver, lung, and testis. Apparently not expressed at detectable levels in kidney, stomach, ovary, heart, and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001758	retinal dehydrogenase activity
GO:0003995	acyl-CoA dehydrogenase activity
GO:0004028	3-chloroallyl aldehyde dehydrogenase activity
GO:0004029	aldehyde dehydrogenase (NAD) activity
GO:0016491	oxidoreductase activity
GO:0018479	benzaldehyde dehydrogenase (NAD+) activity
GO:0042802	identical protein binding

Biological Process

GO:0001822	kidney development
GO:0001889	liver development
GO:0002072	optic cup morphogenesis involved in camera-type eye development
GO:0002138	retinoic acid biosynthetic process
GO:0006979	response to oxidative stress
GO:0007494	midgut development
GO:0008152	metabolic process
GO:0008218	bioluminescence
GO:0014070	response to organic cyclic compound
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0042493	response to drug
GO:0042572	retinol metabolic process
GO:0042573	retinoic acid metabolic process
GO:0042904	9-cis-retinoic acid biosynthetic process
GO:0042905	9-cis-retinoic acid metabolic process
GO:0043065	positive regulation of apoptotic process
GO:0045471	response to ethanol
GO:0048048	embryonic eye morphogenesis
GO:0051289	protein homotetramerization
GO:0055114	oxidation-reduction process
GO:0060206	estrous cycle phase