InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aldh1a1

Summary

InnateDB Gene

IDBG-151900.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh1a1

Gene Name

aldehyde dehydrogenase family 1, subfamily A1

Synonyms

Ahd-2; Ahd2; Aldh1; Aldh1a2; E1; Raldh1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000053279

Encoded Proteins

IDBP-151902

aldehyde dehydrogenase family 1, subfamily A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165092:
The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:20601961-20643462

Strand

Forward strand

Band

Transcripts

ENSMUST00000087638

ENSMUSP00000084918

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001758	retinal dehydrogenase activity
GO:0003995	acyl-CoA dehydrogenase activity
GO:0004028	3-chloroallyl aldehyde dehydrogenase activity
GO:0004029	aldehyde dehydrogenase (NAD) activity
GO:0016491	oxidoreductase activity
GO:0018479	benzaldehyde dehydrogenase (NAD+) activity
GO:0042802	identical protein binding

Biological Process

GO:0001822	kidney development
GO:0001889	liver development
GO:0002072	optic cup morphogenesis involved in camera-type eye development
GO:0002138	retinoic acid biosynthetic process
GO:0006979	response to oxidative stress
GO:0007494	midgut development
GO:0008152	metabolic process
GO:0008218	bioluminescence
GO:0014070	response to organic cyclic compound
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0042493	response to drug
GO:0042572	retinol metabolic process
GO:0042573	retinoic acid metabolic process
GO:0042904	9-cis-retinoic acid biosynthetic process
GO:0042905	9-cis-retinoic acid metabolic process
GO:0043065	positive regulation of apoptotic process
GO:0045471	response to ethanol
GO:0048048	embryonic eye morphogenesis
GO:0051289	protein homotetramerization
GO:0055114	oxidation-reduction process
GO:0060206	estrous cycle phase