InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bche

Summary

InnateDB Protein

IDBP-152027.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bche

Protein Name

butyrylcholinesterase

Synonyms

C730038G20Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029367

InnateDB Gene

IDBG-152025 (Bche)

Protein Structure

UniProt Annotation

Function

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. {ECO:0000269PubMed:17212694, ECO:0000269PubMed:17467011}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Present in most cells except erythrocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003990	acetylcholinesterase activity
GO:0004104	cholinesterase activity
GO:0016787	hydrolase activity
GO:0033265	choline binding
GO:0042802	identical protein binding
GO:0052689	carboxylic ester hydrolase activity

Biological Process

GO:0007271	synaptic transmission, cholinergic
GO:0007584	response to nutrient
GO:0007612	learning
GO:0008152	metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0014016	neuroblast differentiation
GO:0019695	choline metabolic process
GO:0042493	response to drug
GO:0043279	response to alkaloid
GO:0050805	negative regulation of synaptic transmission
GO:0051384	response to glucocorticoid
GO:0051593	response to folic acid

Cellular Component

GO:0005615	extracellular space
GO:0005641	nuclear envelope lumen
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0016020	membrane
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

MGI:894278

InterPro

IPR000997 Cholinesterase
IPR002018 Carboxylesterase, type B
IPR013094 Alpha/beta hydrolase fold-3
IPR014788 Acetylcholinesterase, tetramerisation domain
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00135
PF07859
PF08674

PRINTS

PR00878

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q03311