InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bche

Summary

InnateDB Gene

IDBG-152025.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bche

Gene Name

butyrylcholinesterase

Synonyms

C730038G20Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027792

Encoded Proteins

IDBP-152027

butyrylcholinesterase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114200:
Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:73635808-73708415

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029367	ENSMUSP00000029367
ENSMUST00000133690
ENSMUST00000138216
ENSMUST00000153917

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003990	acetylcholinesterase activity
GO:0004104	cholinesterase activity
GO:0016787	hydrolase activity
GO:0033265	choline binding
GO:0042802	identical protein binding
GO:0052689	carboxylic ester hydrolase activity

Biological Process

GO:0007271	synaptic transmission, cholinergic
GO:0007584	response to nutrient
GO:0007612	learning
GO:0008152	metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0014016	neuroblast differentiation
GO:0019695	choline metabolic process
GO:0042493	response to drug
GO:0043279	response to alkaloid
GO:0050805	negative regulation of synaptic transmission
GO:0051384	response to glucocorticoid
GO:0051593	response to folic acid

Cellular Component

GO:0005615	extracellular space
GO:0005641	nuclear envelope lumen
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0016020	membrane
GO:0072562	blood microparticle