InnateDB Protein
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IDBP-152063.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Apoc1
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Protein Name
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apolipoprotein C-I
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Synonyms
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apo-CI; Apo-CIB; apoC-I; ApoC-IB;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000045571
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InnateDB Gene
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IDBG-152061 (Apoc1)
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Protein Structure
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Function |
Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. {ECO:0000269PubMed:17339654}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Secreted in plasma.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006641
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triglyceride metabolic process
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GO:0008203
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cholesterol metabolic process
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GO:0010900
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negative regulation of phosphatidylcholine catabolic process
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GO:0010916
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negative regulation of very-low-density lipoprotein particle clearance
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GO:0032375
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negative regulation of cholesterol transport
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GO:0033344
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cholesterol efflux
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GO:0033700
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phospholipid efflux
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GO:0034369
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plasma lipoprotein particle remodeling
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GO:0034382
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chylomicron remnant clearance
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GO:0034447
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very-low-density lipoprotein particle clearance
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GO:0042157
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lipoprotein metabolic process
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GO:0045717
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negative regulation of fatty acid biosynthetic process
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GO:0048261
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negative regulation of receptor-mediated endocytosis
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GO:0051005
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negative regulation of lipoprotein lipase activity
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Cellular Component |
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PDB ID |
MGI:88053
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InterPro |
IPR006781
Apolipoprotein C-I
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PFAM |
PF04691
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P34928
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PhosphoSite |
PhosphoSite-P34928
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11812
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UniGene |
|
RefSeq |
NP_001103479
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MGI ID |
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MGI Symbol |
Apoc1
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OMIM |
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CCDS |
CCDS39802
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HPRD |
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IMGT |
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EMBL |
AK011358
BC019398
BC094638
Z22660
Z22661
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GenPept |
AAH19398
AAH94638
BAB27566
CAA80375
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